Il muscolo grande romboide si trova nella parte superiore del dorso ed è ricoperto dal muscolo trapezio; esso origina dai processi spinosi della 1a-4a vertebra toracica e si inserisce al margine vertebrale della scapola al di sotto della spina.
Ha la stessa funzione del muscolo piccolo romboide: fa aderire strettamente la scapola al torace, la eleva, la ruota internamente e la adduce. Se particolarmente debole può portare al distacco delle scapole dalla gabbia toracica (scapole alate).
E' innervato dal nervo dorsale della scapola (C4-C5).
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